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Literature summary for 2.3.1.286 extracted from

  • Cohen, H.Y.; Miller, C.; Bitterman, K.J.; Wall, N.R.; Hekking, B.; Kessler, B.; Howitz, K.T.; Gorospe, M.; de Cabo, R.; Sinclair, D.A.
    Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase (2004), Science, 305, 390-392.
    View publication on PubMed
Search for more literature for 2.3.1.286

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382 Homo sapiens
-
 nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382 Rattus norvegicus
-
 nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96EB6
-
-
Rattus norvegicus Q96EB6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
visceral fat
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
-
 Homo sapiens nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
-
 Rattus norvegicus nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT1
-
 Homo sapiens
SIRT1
-
 Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens expression of SIRT1 is induced in human cells that are treated with human serum. Insulin and insulin-like growth factor 1 (IGF-1) attenuate this response up
Rattus norvegicus expression of SIRT1 is induced in rat cells that are treated with rat serum. Insulin and insulin-like growth factor 1 (IGF-1) attenuate this response up
Rattus norvegicus tissues are extracted from 12-month-old rats that had either been fed ad libitum (AL) or a caloric restriction diet (CR, 60% of AL) since weaning. Compared to expression in AL animals, SIRT1 expression is higher in many tissues of the CR animals, including brain, visceral fat pads, kidney, and liver up

General Information

General Information Comment Organism
metabolism caloric restriction can extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells Homo sapiens
metabolism caloric restriction can extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells Rattus norvegicus